Mass Spectrometry Handbook

  • 40h 47m
  • Mike S. Lee
  • John Wiley & Sons (US)
  • 2012

Due to its enormous sensitivity and ease of use, mass spectrometry has grown into the analytical tool of choice in most industries and areas of research. This unique reference provides an extensive library of methods used in mass spectrometry, covering applications of mass spectrometry in fields as diverse as drug discovery, environmental science, forensic science, clinical analysis, polymers, oil composition, doping, cellular research, semiconductor, ceramics, metals and alloys, and homeland security. The book provides the reader with a protocol for the technique described (including sampling methods) and explains why to use a particular method and not others. Essential for MS specialists working in industrial, environmental, and clinical fields.

About the Author

Mike S. Lee is President of Milestone Development Services where he consults and develops workshops and symposia to support industry with innovative technologies and solutions. His research interests include the application of mass spectrometry for the analysis of proteins, natural products, drug metabolites, impurities, and degradants. Recently, he has been involved in the development of automated orthogonal control systems for electrospray ionization and the development of digital separation devices for sampling, separation, and enrichment.

In this Book

  • Foreword
  • Targeted Proteomics Using Immunoaffinity Purification
  • Mass Spectrometry-Based Methods to Investigate Posttranslational Protein Modifications by Lipid Peroxidation Products
  • Imaging Mass Spectrometry (IMS) for Biological Application
  • Methodologies for Identifying Microorganisms and Viruses by Mass Cataloging of RNAS
  • Preclinical Pharmacokinetics—Industrial Perspective
  • LC-MS in Drug Metabolism and Pharmacokinetics—A Pharmaceutical Industry Perspective
  • Quantitative Mass Spectrometry in Support of Pharmacokinetic Studies
  • Determination of Pharmacokinetic Parameters by HPLC-MS/MS and UPLC-MS/MS
  • Methods for Screening Enantioselective Interactions in the Solution Phase Using ESI-MS
  • Hydrogen/Deuterium Exchange Mass Spectrometry (HDX MS) in the Studies of Architecture, Dynamics, and Interactions of Biopharmaceutical Products
  • TOF-SIMS Applications to Bioimaging and Biomolecule Evaluation Methods
  • Accelerator Mass Spectrometry in Pharmaceutical Development
  • Mass Spectrometry in Clinical Analysis—Screening for Inborn Errors in Metabolism
  • Mass Spectrometry for Steroid Analysis
  • Forensic Applications of Isotope Ratio Mass Spectrometry
  • Analysis of Triacetone Triperoxide Explosive by Mass Spectrometry
  • Mass Spectrometry in Solar System Exploration
  • Application of GC × GC-TOFMS to the Characterization of Extraterrestrial Organic Matter
  • Methods of Mass Spectrometry in Homeland Security Applications
  • Homeland Security
  • Mass Spectrometry in Homeland Security
  • Measurements of Surface contaminants and Sorbed Organics Using an Ion Trap Secondary Ion Mass Spectrometer
  • Determination of Actinides—Determination of Low-Concentration Urine Uranium 235/238 Isotope Ratios
  • Mass Spectrometry in Agriculture, Food, and Flavors—Selected Applications
  • Top-Down Proteomic Identification of Protein Biomarkers of Food-Borne Pathogens Using MALDI-TOF-TOF-MS/MS
  • Determination of Dithiocarbamate Fungicides in Food by Hydrophilic Interaction Liquid Chromatography/Mass Spectrometry
  • Disinfectant and By-Product Analysis in Water Treatment by Membrane Introduction Mass Spectrometry
  • Proton Transfer Reaction Mass Spectrometry (PTR-MS)
  • Determination of Chlorinated Compounds in Dialysis Water and in Biological Fluids/Matrices
  • Mass Spectrometry Techniques for Analysis of Oil and Gas Trapped in Fluid Inclusions
  • LA-MC-ICP-MS Applied to U-PB Zircon Geochronology
  • Hydrocarbon Processing
  • Hydrocarbon Processing—MALDI-MS of Polydisperse Hydrocarbon Samples
  • Renewable Energy—Mass Spectrometry in Biofuel Research
  • Mass Spectrometry in Archaeology
  • Archaeometric Data from Mass Spectrometric Analysis of Organic Materials—Proteins, Lipids, Terpenoid Resins, Lignocellulosic Polymers, and Dyestuff
  • Laser Ablation ICP-MS in Archaeology
  • Spatially Resolved MS in the Study of Art and Archaeological Objects
  • Laser Ablation-Inductively Coupled Plasma Mass Spectrometry for the Investigation of Archaeological Samples
  • Mass Spectrometry in Semiconductor Research
  • Analysis of thin and Thick Films
  • SIMS for Organic Film Analysis
  • Ceramics—Contribution of Secondary Ion Mass Spectrometry (SIMS) to the Study of Crystal Chemistry of Mica Minerals
  • ETV-ICPMS for Analysis of Polymers
  • Polymers
  • Mass Spectroscopy in Polymer Research
  • Laser Mass Spectrometry Applied to the Analysis of Polymers
  • Measuring Thermodynamic Properties of Metals and Alloys
  • High-Performance Thin-Layer Chromatography-Mass Spectrometry for Analysis of Small Molecules
  • Laser Ionization Mass Spectrometry of Inorganic Ions
  • Mass Spectrometry in the SSITKA Studies
  • Proton Transfer Reaction Mass Spectrometry—Applications in the Life Sciences