History Of Modern Biomanufacturing

  • 11 videos | 54m 28s
  • Includes Assessment
Learn about the history of modern biomanufacturing and understand foundational principals for the structure


  • Understand the importance of biologic drugs
    Understand what biologic drugs are
    Understand the history of modern biomanufacturing
    Understand how to use cells to manufacture chemicals
    Understand how to use cells to manufacture penicillin and vaccines
    Understand the history of proteins as therapeutics
  • Understand how insulin was discovered
    Understand how to isolate of protein therapeutics from plasma
    Understand where modern biomanufacturing comes from
    Understand biomanufacturing as a vehicle to deliver high-quality biologics
    Understand how manufacturing biologics works


  • 3m 22s
    In the following video, Professor Chris Love illustrates the importance of biologic drugs by telling the story of Brian Berman, a young boy with Gaucher's Disease. FREE ACCESS
  • 4m 7s
    In the following video, Dr. Stacy Springs will discuss defining the term "biologic drug" and how we will use it throughout the course. She will also begin to teach you why biologics must be engineered and manufactured to be efficacious. FREE ACCESS
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    3.  Intro to the History of Modern Biomanufacturing
    3m 50s
    In the following video, Dr. Paul Barone explores the early history of humans using cells for manufacturing. We start 9,000 years ago in China and end with Louis Pasteur's exploration of fermentation FREE ACCESS
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    4.  Using Cells to Manufacture Chemicals
    5m 1s
    In the following video, Professor Love will explain how war led to the development of cell culture processes to manufacture chemicals and describe the first use of aseptic processing, which is an important component of modern biomanufacturing. FREE ACCESS
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    5.  Using Cells to Manufacture Penicillin and Vaccines
    6m 17s
    In the following video, Dr. Springs will describe how the mold from a cantaloupe could be used to manufacture the "miracle drug" penicillin and how the culture of monkey cells could be used to produce a vaccine against polio. FREE ACCESS
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    6.  The History of Proteins as Therapeutics: Anti-Toxins
    3m 57s
    In this video, Dr. Barone explains how an inactivated bacterial toxin was used to manufacture the first anti-toxin, a cure for diphtheria. He also discusses the main drawbacks of such therapeutics. FREE ACCESS
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    7.  The Discovery And Isolation Of Insulin
    5m 56s
    In the following video, Professor Love will talk about the discovery of insulin in more detail. He will also discuss how insulin was first manufactured and the challenges that were faced in scaling up production of this life-saving medication FREE ACCESS
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    8.  Isolation of Protein Therapeutics from Plasma
    5m 14s
    In this video, Dr. Springs goes into more detail by explaining how albumin and Factor VIII were manufactured using a process called "plasma fractionation." These protein therapeutics have saved countless lives since their discovery FREE ACCESS
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    9.  The Birth of Modern Biomanufacturing
    7m 6s
    In this video, Dr. Barone tells you the story of how Genzyme came to use recombinant DNA technology to manufacture a biologic medicine for Gaucher's disease. FREE ACCESS
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    10.  The Vehicle to Deliver High-Quality Biologics
    5m 13s
    Professor Love will introduce modern biopharmaceutical manufacturing. He will tell you about the four key steps involved in manufacturing a biologic medicine: Cell Line Development, Upstream Processing, Downstream Processing, and Fill & Finish. FREE ACCESS
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    11.  Meet The Experts: Robert Kenyon
    4m 25s
    Meet Robert Kenyon. He is the Vice President and General Manager for Biogen’s Cambridge, MA manufacturing site. He has over 20 years experience in biologics manufacturing all with Biogen. He has held a variety of roles at Biogen, from an intern, running bioreactors and chromatography columns, to Director of Quality. FREE ACCESS


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