Upstream Processing

Everyone
  • 11 videos | 55m 51s
  • Includes Assessment
Learn about upstream processing in biomanufacturing

WHAT YOU WILL LEARN

  • Understand the basics of upstream processing
    Understand how to calculate yield
    Undestand the principles of cultivation
    Understand how bioreactors support cellular metabolism
    Understand bioreactor design features
    Understand the parts of a bioreactor
  • Understand the parts of a bioreactor
    Understand the principles of oxygen transfer
    Understand the principles of mechanical agitation
    Understand how to calculate shear stress
    Understand how wave reactors work

IN THIS COURSE

  • 5m 20s
    In the following video, Professor Love will discuss upstream processing concepts in more detail and explain the fundamentals of cultivating cells for the production of biologic drugs. FREE ACCESS
  • 7m 31s
    In the following tablet capture segment, Nicholas Mozdzierz, graduate student in the Department of Chemical Engineering at MIT, guides you through a sample problem focusing on upstream process yield. FREE ACCESS
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    3.  Principles of Cultivation
    6m 31s
    In the following video, Professor Love discusses cultivation topics in more detail. FREE ACCESS
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    4.  Bioreactors Support Cellular Metabolism
    4m 47s
    As you learned in the previous section, a bioreactor must provide the necessary raw materials to support cellular metabolism. In the following video, Professor Love will discuss this topic in more detail. FREE ACCESS
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    5.  Bioreactor Design Features
    2m 55s
    In the following video, Professor Love will discuss how you design a bioreactor to supply nutrients & oxygen, remove byproducts, and maintain a uniform environment, all to support cellular metabolism and the production of a target biologic. FREE ACCESS
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    6.  The Bioreactor Deconstructed: Part 1
    4m 45s
    Now that we've covered the different pieces of a bioreactor, it's time to see what one looks like in action. In the following video, Professor Love takes a field trip to Biogen. There, he is shown all of the components of a bench-top bioreactor and how they fit together. FREE ACCESS
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    7.  The Bioreactor Deconstructed: Part 2
    3m 8s
    You've just seen most of the components of a bench-top bioreactor. In the following video, Professor Love finishes his field trip to Biogen. His guide, Senior Engineer Alan Gilbert, shows him the tubing used to add media, or other components, to the reactor and the probes used to monitor pH and dissolved oxygen. FREE ACCESS
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    8.  Principles Of Oxygen Transfer
    6m 10s
    In the following video, Professor Love discusses the principles of oxygen transfer in more detail. Understanding this will help you design a bioreactor and determine operating conditions that support cell growth and allow for optimal protein production. FREE ACCESS
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    9.  Principles Of Mechanical Agitation
    5m 8s
    In the following video, Professor Love discusses these impeller designs in more detail and talks about their advantages and disadvantages for cell culture. FREE ACCESS
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    10.  Example Problem: Calculating Shear Stress
    6m 32s
    In the following tablet capture segment, Nicholas Mozdzierz, a graduate student in the Department of Chemical Engineering at MIT, guides you through a sample problem focusing on shear stress. FREE ACCESS
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    11.  The Wave Reactor In Action
    3m 3s
    In the following video, Professor Love visits Pfizer's Pilot Plant in Andover, MA. While there, he talks with John Coyne about the WAVE Bioreactor. FREE ACCESS

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